Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 272
2016
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Methods of biochemical research
Rok: 2016, druh: Uspořádání workshopu
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MS Instrumentation training for students
Rok: 2016, druh: Uspořádání workshopu
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NMR solution structure determination of large RNA-protein complexes
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, rok: 2016, ročník: 97, vydání: November, DOI
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Non-Enzymatic Oligomerization of 3 ', 5 ' Cyclic AMP
Plos one, rok: 2016, ročník: 11, vydání: 11, DOI
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Open day for MU students
Rok: 2016, druh: Popularizační texty
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Phenanthrylene-butadiynylene and Phenanthrylene-thienylene Macrocycles: Synthesis, Structure, and Properties
Journal of Organic Chemistry, rok: 2016, ročník: 81, vydání: 15, DOI
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Propanediurea-Based Molecular Clips Bind Halide Anions: An Insight into the Mechanism of Cucurbituril Formation
Journal of Organic Chemistry, rok: 2016, ročník: 81, vydání: 19, DOI
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Quantitative proteomics of the tobacco pollen tube secretome identifies novel pollen tube guidance proteins important for fertilization
Genome Biology, rok: 2016, ročník: 17, vydání: May, DOI
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Rapid assignment of malting barley varieties by matrix-assisted laser desorption-ionisation - Time-of-flight mass spectrometry
Food Chemistry, rok: 2016, ročník: 206, vydání: September, DOI
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Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate
Proceedings of the National Academy of Sciences of the United States of America, rok: 2016, ročník: 113, vydání: 33, DOI